01 · Advanced age
It becomes more common as people grow older.
LATE most often affects adults in very old age and can contribute to changes in memory and thinking.
LATE information center
LATE: a cause of memory changes in later life.
LATE is a brain disease associated with changes in memory and thinking in very old age. This site offers clear, research-based information for individuals, families, care partners, and clinicians.
A short introduction to LATE and why clearer information matters.
TRC-LATE at a glance
A five-site, NIA-funded study bringing LATE into clearer focus.
420 participants
in the target discovery cohort
5 sites
participating academic research centers
NIA funded
through the National Institute on Aging
Why this matters
LATE is common in advanced age, but it has often been missed or misunderstood.
Learning more about LATE can help people recognize that memory changes in later life may have more than one possible cause.
02 · Similar symptoms
It can look like Alzheimer’s disease.
Similar symptoms make it important to develop better ways to tell conditions apart during life.
03 · Overlap
More than one brain change can be present.
LATE can occur alongside Alzheimer’s disease and other brain changes, which may affect symptoms and care.
Start with the basics
Clear information for the questions people actually have.
LATE is not yet easily diagnosed during life. Learn what researchers know, what remains uncertain, and when it may help to speak with a health professional.
For research professionals
Advancing the science of LATE.
The TRC-LATE Study brings together participants and academic research centers to improve recognition, biomarker discovery, and trial readiness.
5 yearsof participant follow-up
Annual visitsclinical, cognitive, blood, and imaging measures
Research networkacross UCI, UCSD, USC, UW, and OHSU
Have a question about LATE?
Explore the frequently asked questions or contact the study team for general information.