TRC-LATE Study
Understanding LATE and the TRC-LATE Study
LATE is a brain disease that can affect memory and thinking in very old age. This page is for older adults, families, caregivers, and community members who want a clear place to start.
This video introduces TRC-LATE and explains why studying LATE matters for older adults and families.
LATE at a glance
LATE stands for Limbic-Predominant Age-Related TDP-43 Encephalopathy. It is linked to changes in a protein called TDP-43.
LATE most often affects people in their 80s and older. It can cause memory loss and thinking changes that may look similar to Alzheimer’s disease.
Because LATE can look like other memory disorders, it has often been missed or misunderstood. Learning more about it is an important step toward better diagnosis and future treatment studies.
Who is most affected? Adults in very old age, especially people age 80 and older.
What can it look like? Memory loss and thinking changes that can resemble Alzheimer’s disease.
Why is research needed? There are no approved treatments for LATE yet, and better tools are needed to recognize it during life.
Why this matters
Many families know about Alzheimer’s disease, but fewer have heard of LATE. TRC-LATE is helping bring this condition into clearer focus.
It is common in advanced age
LATE becomes more common as people grow older and can contribute to memory loss in later life.
It can be hard to recognize
Symptoms can look like Alzheimer’s disease, so researchers need better ways to tell these conditions apart.
Research can open doors
By learning more about LATE, researchers can prepare for future studies that test ways to diagnose, prevent, or treat it.
What is the TRC-LATE study?
TRC-LATE is a multi-site research study focused on improving what we know about LATE and preparing for future clinical trials. The study brings together academic medical centers with experience in aging and memory research.
Interested in learning more?
If you have questions about LATE or the TRC-LATE study, please contact the study team. We can help direct you to the right person or participating site.