Aim 01
Validate diagnostic markers
Evaluate existing clinical, imaging, and blood-based measures that may help distinguish LATE from other causes of cognitive change.
TRC-LATE Study
For researchers.
Study design, cohort goals, eligibility, measures, and participating sites for a multi-site effort to improve detection and trial readiness for LATE.
420target discovery cohort participants
5 sitesparticipating academic research centers
5 yearsof annual participant follow-up
NIA fundedthrough the National Institute on Aging
Study overview
Bringing LATE into clearer focus.
The study is designed to improve recognition of LATE during life, discover biomarkers, and prepare the field for future clinical trials.
Aim 02
Discover novel biomarkers
Use longitudinal data and biospecimens to identify new markers that can support research and future clinical use.
Aim 03
Advance trial readiness
Build the evidence needed to identify appropriate participants and outcomes for future LATE-focused trials.
Eligibility
Two study pathways.
Eligibility is determined by study staff. The details below summarize the primary pathways for researchers and referring clinicians.
Standard pathway
Adults age 85 and older with a range of cognitive and MRI characteristics relevant to the discovery cohort.
- Clinical and cognitive assessment at enrollment
- Neuroimaging and biospecimen collection
- Consent for postmortem brain examination
Amyloid-negative pathway
Adults age 75 and older with cognitive impairment or dementia who are amyloid negative may be eligible for a targeted pathway.
- Eligibility reviewed at the study site
- Designed to support LATE-focused discovery
- Consent for postmortem brain examination
Participant involvement
Longitudinal assessment with a practical schedule.
Participants complete annual visits and selected remote measures to support a detailed picture of cognition and biomarker change over time.
Annual visitClinical and cognitive assessment, blood collection, and MRI.
Every 2 yearsFDG-PET imaging, when applicable.
Every 6 monthsRemote cognitive assessment.
Annual surveysParticipant and informant questionnaires about health, function, and daily life.
Participating sites
A five-center academic network.
Each center contributes clinical expertise and research infrastructure to a shared longitudinal cohort.
UC IrvineUniversity of California, Irvine
UC San DiegoUniversity of California, San Diego
USCUniversity of Southern California
University of WashingtonSeattle, Washington
OHSUOregon Health & Science University
Interested in collaborating or referring?
Contact the TRC-LATE Study team for site-specific questions, eligibility information, or research collaboration.